Occurrence and Health Risk of Perfluoroalkyl Acids in Popular Shellfish from a Typical Coastal Area of the East China

Abstract

As crucial homologous members of per- and polyfluoroalkyl substances(PFASs), perfluoroalkyl acids(PFAAs) have aroused wide public concern because of their unique properties(persistence, bioaccumulation, long-distance migration and toxicity). Studies have shown their potential hazard to wildlife and humans, with food consumption as one of the primary routes of PFAA exposure for general population, especially seafood intake. In this study, 17 PFAAs were quantified in 9 shellfish species from Yuhuan City, a typical coastal area of the East China. The total mean concentrations of PFAAs were in the range of 5.03–381 ng/g dry weight(dw), with the highest concentration found in Neverita didyma and the lowest in Babylonia lutosa. Concentrations and composition profiles of PFAAs varied significantly among different species, indicating differences in the bioaccumulation potential of PFAAs among species. Perfluorooctanoic acid(PFOA) was presented as the most abundant PFAA in this study, followed by perfluorobutanoic acid(PFBA). Significant positive correlations were observed among some individual PFAAs(p<0.05), indicating that they may share similar pollution sources or undergo similar compound behaviors. Health risk assessment indicated a relatively high threat for local residents exposed to PFAAs through shellfish consumption.

Keywords

Perfluoroalkyl acid / Shellfish / East China Sea / Occurrence / Health risk assessment

References

[1] Buck R C, Jensen A A. Integrated Environmental Assessment and Management, 2011, 7(4): 513.

[2] Sznajder-Katarzyńska K, Surma M, Cieślik I. Journal of Chemistry, 2019, 2019: 1.

[3] Gomis M I, Wang Z, Scheringer M, Cousins I T. Science of the Total Environment, 2015, 505: 981.

[4] Pelch K E, Reade A, Wolffe T A M, Kwiatkowski C F. Environment International, 2019, 130: 10485.

[5] Winquist A, Steenland K. Epidemiology, 2014, 25(2): 255.

[6] Nelson J W, Hatch E E, Webster T F. Environmental Health Perspectives, 2010, 118(2): 197.

[7] Okada E, Sasaki S, Saijo Y, Washino N, Miyashita C, Kobayashi S, Konishi K, Ito Y M, Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H, Kishi R. Environmental Research, 2012, 112: 118.

[8] Steenland K, Zhao L, Winquist A, Parks C. Environmental Health Perspectives, 2013, 121(8): 900.

[9] Barry V, Winquist A, Steenland K. Environmental Health Perspectives, 2013, 121(11/12): 1313.

[10] Darrow L A, Stein C R, Steenland K. Environmental Health Perspectives, 2013, 121(10): 1207.

[11] Lam J, Koustas E, Sutton P, Johnson P I, Atchley D S, Sen S, Robinson K A, Axelrad D A, Woodruff T J. Environmental Health Perspectives, 2014, 122(10): 1040.

[12] Taniyasu S, Kannan K, Horii Y, Hanari N, Yamashita N. Environ. Sci. Technol., 2003, 37(12): 2634.

[13] Sammut G, Sinagra E, Sapiano M, Helmus R, de Voogt P. Science of the Total Environment, 2019, 682: 180.

[14] Ahrens L, Bundschuh M. Environmental Toxicology and Chemistry, 2014, 33(9): 1921.

[15] Zhang A, Wang P, Lu Y, Zhang M, Zhou Y, Wang Y, Zhang S. Science of the Total Environment, 2019, 665: 1026.

[16] Vestergren R, Cousins I T. Environ. Sci. Technol., 2009, 43(15): 5565.

[17] Zhang T, Sun H, Lin Y, Wang L, Zhang X, Liu Y, Geng X, Zhao L, Li F, Kannan K. J. Agric. Food Chem., 2011, 59: 11168.

[18] Haug L S, Thomsen C, Brantsæter A L, Kvalem H E, Haugen M, Becher G, Alexander J, Meltzer H M, Knutsen H K. Environment International, 2010, 36: 772.

[19] Heo J-J, Lee J-W, Kim S-K, Oh J-E. Journal of Hazardous Materials, 2014, 279: 402.

[20] Dassuncao C, Hu X C, Nielsen F, Weihe P, Grandjean P, Sunderland E M. Environ. Sci. Technol., 2018, 52(6): 3738.

[21] Shen A, Lee S, Ra K, Suk D, Moon H-B. Marine Pollution Bulletin, 2018, 128: 287.

[22] Han T, Gao L, Chen J, He X, Wang B. Environmental Pollution, 2020, 265: 115011.

[23] Hu H, Zhang Y, Zhao N, Xie J, Zhou Y, Zhao M, Jin H. Science of the Total Environment, 2021, 797: 149052.

[24] Guéguen M, Amiard J-C, Arnich N, Badot P-M, Claisse D, Guérin T, Vernoux J-P. Reviews of Environmental Contamination and Toxicology, 2011, 213: 55.

[25] Li L, Zheng H, Wang T, Cai M, Wang P. Environmental Pollution, 2018, 238: 168.

[26] Wu Y, Wang Y, Li J, Zhao Y, Guo F, Liu J, Cai Z. Environment International, 2012, 42: 67.

[27] Meng L, Lu Y, Wang Y, Ma X, Li J, Lv J, Wang Y, Jiang G. ACS EST Water, 2022, 2: 195.

[28] Gao K, Miao X, Fu J, Chen Y, Li H, Pan W, Fu J, Zhang Q, Zhang A, Jiang G. Environmental Pollution, 2020, 257: 113383.

[29] Vassiliadou I, Costopoulou D, Kalogeropoulos N, Karavoltsos S, Sakellari A, Zafeiraki E, Dassenakis M, Leondiadis L. Chemosphere, 2015, 127: 117.

[30] Yang X, Li Y, Ma G, Hu X, Wang J, Cui Z, Wang Z, Yu W, Yang Z, Zhai F. Zhonghua Liuxingbingxue Zazhi, 2005, 26: 489.

[31] Zhao X, Duan X. Exposure Factors Handbook of Chinese Population (Children 6–17 Years), 2010.

[32] Gulkowska A, Jiang Q, So M K, Taniyasu S, Lam P K S, Yamashita N. Environ. Sci. Technol., 200, 40: 3736.

[33] Barnes D G, Dourson M. Regulatory Toxicology and Pharmacology, 1988, 8(4): 471.

[34] EFSA Panel on Contaminants in the Food ChainEFSA CONTAM Panel EFSA Journal, 2020, 18(9): 6223.

[35] Wang G, Lu J, Xing Z, Li S, Liu Z, Tong Y. International Journal of Environmental Research and Public Health, 2017, 14: 970.

[36] Olsen G W, Chang S-C, Noker P E, Gorman G S, Ehresman D J, Lieder P H, Butenhoff J L. Toxicology, 2009, 256: 65.

[37] Wang Z, Cousins I T, Scheringer M, Buck R C, Hungerbühler K. Environment International, 2014, 70: 62.

[38] Habibullah-Al-Mamun M, Ahmed Md K, Raknuzzaman M, Islam Md S, Ali M M, Tokumura M, Masunaga S. Marine Pollution Bulletin, 2017, 124: 775.

[39] Ali A M, Sanden M, Higgins C P, Hale S E, Alarif W M, Al-Lihaibi S S, Ræder E M, Langberg H A, Kallenborn R. Environmental Pollution, 2021, 280: 116935.

[40] Munschy C, Bely N, Pollono C, Aminot Y. Chemosphere, 2019, 228: 640.

[41] Lee J-W, Lee H-K, Lim J-E, Moon H -B. Chemosphere, 2020, 251: 126633.

[42] Pan C-G, Xiao S-K, Yu K-F, Wu Q, Wang Y -H. Journal of Hazardous Materials, 2021, 403: 123618.

[43] Diao J, Chen Z, Wang T, Su C, Sun Q, Guo Y, Zheng Z, Wang L, Li P, Liu W, Hong S, Khim J S. Journal of Hazardous Materials, 2022, 431: 128602.

[44] Ruffle B, Vedagiri U, Bogdan D, Maier M, Schwach C, Murphy-Hagan C. Environmental Research, 2020, 190: 109932.

[45] Zhang Z, Gong Y, Cao W, Hu D. Science and Technology of Food Industry, 2021, 42(8): 410.

[46] Liu H, Xu M, Wu C. Journal of Food Science, 2013, 34(5): 228.

[47] Han X, Snow T A, Kemper R A, Jepson G W. Chem. Res. Toxicol., 2003, 16: 775.

[48] Zhang L, Ren X -M, Guo L -H. Environ. Sci. Technol., 2013, 47: 11293.

[49] Hong S, Khim J S, Wang T, Naile J E, Park J, Kwon B-O, Song S J, Ryu J, Codling G, Jones P D, Lu Y, Giesy J P. Chemosphere, 2015, 129: 157.

[50] Xiao B, Zhu W, Qin Q, Kong Y, Su Y. China Standardization, 2021, 580: 144.

[51] Zheng H, Gao J. Marine Sciences, 2002, 264: 52.

[52] Wang Y, Zhong H, Luo Y, Xian H, Li F, Gao W, Wang Y, Jiang G. Science of the Total Environment, 2021, 777: 146101.

[53] Houde M, Bujas T A D, Small J, Wells R S, Fair P A, Bossart G D, Solomon K R, Muir D C G. Environ. Sci. Technol., 200, 40: 4138.

[54] Yu H, Wang Y, Shao J. Marine Fisheries, 2003, 25(4): 198.

[55] Jin Q, Shi Y, Cai Y. Science of the Total Environment, 2020, 726: 138538.

[56] Zhang Y, Liu X, Yu L, Hua Z, Zhao L, Xue H, Tong X. Journal of Environmental Management, 2022, 317: 115390.

[57] Li Y, Li J, Zhang L, Huang Z, Liu Y, Wu N, He J, Zhang Z, Zhang Y, Niu Z. Environment International, 2019, 123: 87.

[58] Chu K, Lu Y, Hua Z, Liu Y, Ma Y, Gu L, Gao C, Yu L, Wang Y. Environmental Pollution, 2022, 296: 118748.

[59] Du D, Lu Y, Zhou Y, Li Q, Zhang M, Han G, Cui H, Jeppesen E. Journal of Hazardous Materials, 2021, 405: 124681.