Construction and Application of DNAzyme-based Nanodevices
Bo Wang , Menghui Wang , Fangqi Peng , Xiaoyi Fu , Mei Wen , Yuyan Shi , Mei Chen , Guoliang Ke , Xiao-Bing Zhang
Chemical Research in Chinese Universities ›› 2023, Vol. 39 ›› Issue (1) : 42 -60.
Construction and Application of DNAzyme-based Nanodevices
The development of stimuli-responsive nanodevices with high efficiency and specificity is very important in biosensing, drug delivery, and so on. DNAzymes are a class of DNA molecules with the specific catalytic activity. Owing to their unique catalytic activity and easy design and synthesis, the construction and application of DNAzymes-based nanodevices have attracted much attention in recent years. In this review, the classification and properties of DNAzyme are first introduced. The construction of several common kinds of DNAzyme-based nanodevices, such as DNA motors, signal amplifiers, and logic gates, is then systematically summarized. We also introduce the application of DNAzyme-based nanodevices in sensing and therapeutic fields. In addition, current limitations and future directions are discussed.
DNAzyme / Nanodevice / Biosensor / Therapy
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Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH
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