Fabrication of Mesoporous SiO₂@CaSiO₃ Hollow Spheres as Carriers for pH-sensitive Drug Delivery

Abstract

Hollow mesoporous silica(HM-SiO₂) was prepared by the improved stober method. On this basis, HM-SiO₂ was dispersed in an alkaline solution for surface etching. Meanwhile, calcium source was introduced to combine with SiO ₃ ²⁻ on the surface to form a CaSiO₃ shell layer and an unprecedent SiO₂@CaSiO₃ sphere with a hollow double-shell structure was obtained. The as-synthesized SiO₂@CaSiO₃ was characterized by X-ray diffraction(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM), N₂-BET, IR and UV-Vis techniques, and its sustained release capacity of doxorubicin(DOX) loading was investigated. The drug loading capacity can be achieved to 0.692 mg DOX/mg SiO₂@CaSiO₃, exhibiting pH-responsivity under low pH conditions.

Keywords

Hollow nano-sphere / SiO₂@CaSiO₃ / Drug delivery / pH-sensitive

References

[1] Torchilin V P. Nat. Rev. Drug Discov., 2014, 13(11): 813.

[2] Blanco E, Shen H, Ferrari M. Nat. Biotechnol., 2015, 33(9): 941.

[3] Wang S. Micropor. Mesopor. Mat., 2009, 117(1/2): 1.

[4] Cheng L, Wang C, Feng L, Yang K, Liu Z. Chem. Rev., 2014, 114(21): 10869.

[5] Suk J S, Xu Q, Kim N, Hanes J, Ensign L M. Adv. Drug. Deliv. Rev., 201, 99: 28. Pt. A

[6] Karimi M, Ghasemi A, SahandiZangabad P, Rahighi R, MoosaviBasri S M, Mirshekari H, Amiri M, ShafaeiPishabad Z, Aslani A, Bozorgomid M, Ghosh D, Beyzavi A, Vaseghi A, Aref A R, Haghani L, Bahrami S, Hamblin M R. Chem. Soc. Rev., 201, 45(5): 1457.

[7] Hou X, Zhao C, Tian Y, Dou S, Zhang X, Zhao J. Chem. Res. Chinese Universities, 201, 32(6): 889.

[8] Tu X, Wang L, Cao Y, Ma Y, Shen H, Zhang M, Zhang Z. Carbon, 201, 97: 35.

[9] Wu P, Zhou D, Huang Y, Li J. Chem. Res. Chinese Universities, 2018, 34(4): 676.

[10] Rong Z, Sun W, Xiao H, Jiang G. Cement Concrete Comp., 2015, 56: 25.

[11] Islam M S, Choi H N, Choi W S, Lee H-J. J. Mater. Chem. B, 2015, 3(6): 1001.

[12] Lu B-Q, Zhu Y-J, Cheng G-F, Ruan Y-J. Mater. Lett., 2013, 104: 53.

[13] Chen Z, Yan X, Li M, Wang S, Chen C. Inorg. Chem., 2021, 60(7): 4362.

[14] Li C, Wang J C, Wang Y G, Gao H L, Wei G, Huang Y Z, Yu H J, Gan Y, Wang Y J, Mei L, Chen H B, Hu H Y, Zhang Z P, Jin Y G. Acta Pharm. Sin. B, 2019, 9(6): 1145.

[15] Fenton O S, Olafson K N, Pillai P S, Mitchell M J, Langer R. Adv. Mater., 2018, 30(29): 1.

[16] Zhu Y F, Ikoma T, Hanagata N, Kaskel S. Small, 2010, 6(3): 471.

[17] Wu J, Zhu Y-J, Cao S-W, Chen F. Adv. Mater., 2010, 22(6): 749.

[18] Prasanna A P S, Venkataprasanna K S, Pannerselvam B, Asokan V, Jeniffer R S, Venkatasubbu G D. J. Fluoresc., 2020, 30(5): 1075.

[19] Wu C, Chang J, Fan W. Journal of Materials Chemistry, 2012, 22(33): 16801.

[20] Zhu Y-J, Guo X-X, Sham T-K. Expert Opin. Drug Del., 2017, 14(2): 215.

[21] Ge R, Xun C, Yang J, Jia W, Li Y. Biomed. Mater., 2019, 14(6): 065013.

[22] Teng Z, Su X, Zheng Y, Sun J, Chen G, Tian C, Wang J, Li H, Zhao Y, Lu G. Chem. Mater., 2012, 25(1): 98.

[23] Dou Y, Guo J, Chen Y, Han S, Xu X, Shi Q, Jia Y, Liu Y, Deng Y, Wang R, Li X, Zhang J. J. Control. Release., 201, 235: 48.

[24] Vallet-Regi M, Colilla M, Izquierdo-Barba I, Manzano M. Molecules, 2018, 23(1): 19.

[25] Wu J, Zhu Y-J, Chen F. Small, 2013, 9(17): 2911.

[26] Christoforidou T, Giasafaki D, Andriotis E G, Bouropoulos N, Theodoroula N F, Vizirianakis I S, Steriotis T, Charalambopoulou G, Fatouros D G. Int. J. Mol. Sci., 2021, 22(4): 1896.

[27] Liu L, Liu J, Zhao L, Yang Z, Lv C, Xue J, Tang A. Environ. Sci. Pollut. Res., 2019, 26(9): 8721.

[28] Lin Z T, Wu Y B, Bi Y G. J. Nanopart. Res., 2018, 20(11): 13.