Meta-DNA Strategy to Assemble DNA Structures in Submicrometre and Micrometre Scale

Abstract

To break through the size limitation in DNA structure assembly and to achieve the construction of DNA structures with submicrometre and micrometre scale, Fan and Yan et al. proposed a versatile DNA structure assembly strategy, named as meta-DNA(M-DNA) strategy. Submicrometre-sized M-DNA, which has a six-helix bundle DNA origami nanostructure, is used as building block to precisely assemble a series of submicrometre-to-micrometre-sized DNA architectures with customed shapes, including meta-multi-arm junctions, polyhedrons and closely packed lattices. Besides static assembly, the proposed M-DNA strategy was also demonstrated to work well for the programmed dynamic rearrangement of DNA structures. This work has been published online in the Nature Chemistry on September 7, 2020.

References

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[3] Yao G, Zhang F, Wang F, Peng T, Liu H, Poppleton E, Sulc P, Jiang S, Liu L, Gong C, Jing X, Liu X, Wang L, Liu Y, Fan C, Yan H. Nature Chemistry, 2020, 12: 1067.