Unraveling the Dynamics of Antibody-Antigen Interaction by DNA Origami

Abstract

To investigate the dynamic interaction between antibody and antigen, Fan et al. rationally designed a triangular DNA origami framework to spatially organize the antigenic epitopes at the nanoscale and thus to monitor the transient binding kinetics of the dynamic antigen-antibody complexes at room temperature. This study provides a straightforward, designable and programmable strategy to investigate the transition kinetics of antibody-antigen interaction at a single-molecule level and improve the understanding toward the design of the next-generation antibodies and vaccines for various biomedical applications. This work has been published online in Nature Communications on June 19, 2020.

Keywords

Medical and Health Sciences / Immunology

References

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Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH