Synthesis of A-B-C-ring Tricyclic Core of iso-Merrilactone A

Abstract

A desymmetrization approach for the synthesis of the A-B-C tricycle intermediate of iso-merrilactone A was described. The key steps of this synthesis to efficiently access the tetracyclic Illicium sesquiterpenes core included an intramolecular aldol cyclization and an oxidative lactonization reaction. A novel Au catalyzed hydrolytic cyclorearrangement cascade reaction was explored in the initial stage.

Keywords

Sesquiterpene / Regio-isomer / Cyclorearrangement / Lactonization

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