One-pot Synthesis of PEGylated Gd-based Nanoparticles as High-performance and Biocompatibility Contrast Agents for T 1-Weighted Magnetic Resonance Imaging In vivo

Sa Huang; Qinghe Han; Lei Wang; Tingting Gong; Qinghai Yuan

doi:10.1007/s40242-019-8327-y

Chemical Research in Chinese Universities ›› 2019, Vol. 35 ›› Issue (3) : 537 -541. DOI: 10.1007/s40242-019-8327-y

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One-pot Synthesis of PEGylated Gd-based Nanoparticles as High-performance and Biocompatibility Contrast Agents for T ₁-Weighted Magnetic Resonance Imaging In vivo

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Abstract

Polyethylene glycol modified(PEGylated) NaGdF₄(PEG-NaGdF₄) nanoparticles as a novel T ₁-weighted magnetic resonance imaging(MRI) contrast agent was successfully constructed by a one-pot hydrothermal synthesis method. Because of the functionalization of PEG, the nanoprobes had excellent dispersity, excellent stability and high biocompatibility. More importantly, the as-prepared PEG-NaGdF₄ nanoprobes revealed the high longitudinal relaxivity value and prominent T ₁-weighted MRI contrast performance, which was superior to the commercial MRI contrast agents. With the facile synthesis, excellent dispersity, outstanding stability, remarkable contrast performance and high biocompatibility, the PEGylated NaGdF₄ nanoparticles brought more opportunities to the new generation of nanoparticulate-based T ₁-weighted MRI contrast agents in clinic.

Keywords

Nanoparticulate contrast agent / Polyethylene glycol / T ₁-Weighted magnetic resonance imaging / Biocompatibility

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Sa Huang, Qinghe Han, Lei Wang, Tingting Gong, Qinghai Yuan. One-pot Synthesis of PEGylated Gd-based Nanoparticles as High-performance and Biocompatibility Contrast Agents for T ₁-Weighted Magnetic Resonance Imaging In vivo. Chemical Research in Chinese Universities, 2019, 35(3): 537-541 DOI:10.1007/s40242-019-8327-y

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