PhIO-mediated Synthesis of Ketones from Alkynes and Alkenes

Abstract

A facile and efficient method for the preparation of methyl ketones was developed in the reaction of alkynes and alkenes with PhIO-BF₃∙Et₂O. The reaction features mild conditions, short time and metal-free catalyst. The possible mechanism for the formation of methyl ketones was proposed. H₂O functions as both a nucleophile and an oxygen source.

Keywords

Alkyne / Alkene / Ketone / Hydration reaction

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