Artificial Nucleotide-containing Aptamers Used in Tumor Therapy

Abstract

The high pharmaceutical cost and multi-drug resistance in tumor therapeutic agents hinder the further application of chemotherapy in tumor therapy. Artificial modified nucleic acid aptamers have the advantages of high binding affinity, programmability, and easy synthesis. Thus, the rational design of artificial modified aptamers is expected to provide a versatile platform for the optimization of chemotherapy agents. In this review, we summarize the modification strategies and the application of the artificial modified nucleotide-containing aptamers, aiming to provide a promising step toward aptamer-related chemotherapeutic agents.

Keywords

Aptamer / Artificial nucleotide / Functional nucleic acid

References

[1] T T, J L, C X, Y S, H L, X L, J X, J S, L W, W L, C F. ACS Applied Materials & Interfaces, 2018, 10(4): 3414.

[2] Zeng X, Luo M, Liu G, Wang X, Tao W, Lin Y, Ji X, Nie L, Mei L. Advanced Science, 2018, 5(10): 1800510.

[3] Bian Q, Wang W, Wang S, Wang G. ACS Applied Materials & Interfaces, 2016, 8(40): 27360.

[4] Wang J, Wang Y, Hu X, Zhu C, Ma Q, Liang L, Li Z, Yuan Q. Analytical Chemistry, 2019, 91(1): 823.

[5] Wang J, Shen H, Huang C, Ma Q, Tan Y, Jiang F, Ma C, Yuan Q. Nano Research, 2016, 10(1): 145.

[6] Hu X, Wang Y, Tan Y, Wang J, Liu H, Wang Y, Yang S, Shi M, Zhao S, Zhang Y, Yuan Q. Advanced Materials, 2017, 29(15): 1605235.

[7] Wang J, Wei Y, Hu X, Fang Y Y, Li X, Liu J, Wang S, Yuan Q. Journal of the American Chemical Society, 2015, 137(33): 10576.

[8] Zhang H, Li B, Sun Z, Zhou H, Zhang S. Chemical Science, 2017, 8(12): 8025.

[9] Qiu L, Chen T, Ocsoy I, Yasun E, Wu C, Zhu G, Yo u M, Han D, Jiang J, Yu R, Tan W. Nano Letters, 2015, 15(1): 457.

[10] He J, Dong J, Hu Y, Li G, Hu Y. Nanoscale, 2019, 11(13): 6089.

[11] Chandrasekaran R, Lee A S, Yap L W, Jans D A, Wagstaff K M, Cheng W. Nanoscale, 2016, 8(1): 187.

[12] Jiang Y, Pan X, Chang J, Niu W, Hou W, Kuai H, Zhao Z, Liu J, Wang M, Tan W. Journal of the American Chemical Society, 2018, 140(22): 6780.

[13] Song Y, Tang C, Yin C. Biomaterials, 2018, 150: 1.

[14] Ren X, Gelinas A D, von Carlowitz I, Janjic N, Pyle A M. Nature Communications, 2017, 8(1): 810.

[15] Zhao N, Pei S N, Qi J, Zeng Z, Iyer S P, Lin P, Tung C H, Zu Y. Biomaterials, 2015, 67: 42.

[16] Zhang J, Chen R, Fang X, Chen F, Wang Y, Chen M. Nano Research, 2015, 8(1): 201.

[17] Cogoi S, Jakobsen U, Pedersen E B, Vogel S, Xodo L E. Scientific Reports, 2016, 6: 38468.

[18] Setoguchi K, Cui L, Hachisuka N, Obchoei S, Shinkai K, Hyodo F, Kato K, Wada F, Yamamoto T, Harada-Shiba M, Obika S, Nakano K. Molecular Therapy. Nucleic Acids, 2017, 9: 170.

[19] Yang Y, Yang X, Yang Y, Yuan Q. Carbon, 2018, 129: 380.

[20] Tao W, Zeng X, Wu J, Zhu X, Yu X, Zhang X, Zhang J, Liu G, Mei L. Theranostics, 2016, 6(4): 470.

[21] Tagalakis A D, Maeshima R, Yu-Wai-Man C, Meng J, Syed F, Wu L P, Aldossary A M, McCarthy D, Moghimi S M, Hart S L. Acta Biomaterialia, 2017, 51: 351.

[22] Hwang D W, Kim H Y, Li F, Park J Y, Kim D, Park J H, Han H S, Byun J W, Lee Y S, Jeong J M, Char K, Lee D S. Biomaterials, 2017, 121: 144.

[23] Huang K W, Lai Y T, Chern G J, Huang S F, Tsai C L, Sung Y C, Chiang C C, Hwang P B, Ho T L, Huang R L, Shiue T Y, Chen Y, Wang S K. Biomacromolecules, 2018, 19(6): 2330.

[24] Li J, Hong C Y, Wu S X, Liang H, Wang L P, Huang G, Chen X, Yang H H, Shangguan D, Tan W. Journal of the American Chemical Society, 2015, 137(35): 11210.

[25] Jing P, Cao S, Xiao S, Zhang X, Ke S, Ke F, Yu X, Wang L, Wang S, Luo Y, Zhong Z. Cancer Letters, 2016, 383(2): 230.

[26] Chen D, Li B, Cai S, Wang P, Peng S, Sheng Y, He Y, Gu Y, Chen H. Biomaterials, 2016, 100: 1.

[27] Zhang Y, Hou Z, Ge Y, Deng K, Liu B, Li X, Li Q, Cheng Z, Ma P, Li C, Lin J. ACS Applied Materials & Interfaces, 2015, 7(37): 20696.

[28] Li F, Mei H, Gao Y, Xie X, Nie H, Li T, Zhang H, Jia L. Biomaterials, 2017, 145: 56.

[29] Peng L H, Zhang Y H, Han L J, Zhang C Z, Wu J H, Wang X R, Gao J Q, Mao Z W. ACS Applied Materials & Interfaces, 2015, 7(33): 18628.

[30] Hili R, Niu J, Liu D R. Journal of the American Chemical Society, 2013, 135(1): 98.

[31] Zhao F, Zhou J, Su X, Wang Y, Yan X, Jia S, Du B. Small, 2017, 13(20): 1603990.

[32] Wang R, Lu D, Bai H, Jin C, Yan G. Chemical Science, 2016, 7(3): 2157.

[33] Wang R W, Wang C M, Cao Y, Zhu Z, Yang C Y. Chemical Science, 2014, 5(10): 4076.

[34] Kimoto M, Yamashige R, Matsunaga K, Yokoyama S, Hirao I. Nature Biotechnology, 2013, 31(5): 453.

[35] Matsunaga K I, Kimoto M, Hirao I. Journal of the American Chemical Society, 2017, 139(1): 324.

[36] Biondi E, Lane J D, Das D, Dasgupta S, Piccirilli J A, Hoshika S, Bradley K M, Krantz B A, Benner S A. Nucleic. Acids Research, 2016, 44(20): 9565.

[37] Labenski V, Suerth J D, Barczak E, Heckl D, Levy C, Bernadin O, Charpentier E, Williams D A, Fehse B, Verhoeyen E, Schambach A. Biomaterials, 2016, 97: 97.

[38] Hou W, Liu Y, Jiang Y, Wu Y, Cui C, Wang Y, Zhang L, Teng I T, Tan W. Nanoscale, 2018, 10(23): 10986.

[39] Chen W, Liu X, Xiao Y, Tang R. Small, 2015, 11(15): 1775.

[40] Khaled S Z, Cevenini A, Yazdi I K, Parodi A, Evangelopoulos M, Corbo C, Scaria S, Hu Y, Haddix S G, Corradetti B, Salvatore F, Tasciotti E. Biomaterials, 2016, 87: 57.

[41] Kanlikilicer P, Ozpolat B, Aslan B, Bayraktar R, Gurbuz N, Rodriguez-Aguayo C, Bayraktar E, Denizli M, Gonzalez-Villasana V, Ivan C, Lokesh G L ^R, Amero P, Catuogno S, Haemmerle M, Wu S Y, Mitra R, Gorenstein D G, Volk D E, de Franciscis V, Sood A K, Lopez-Berestein G. Molecular Therapy. Nucleic Acids, 2017, 9: 251.

[42] Zhang F, Correia A, Makila E, Li W, Salonen J, Hirvonen J J, Zhang H, Santos H A. ACS Applied Materials & Interfaces, 2017, 9(11): 10034.

[43] Abnous K, Danesh N M, Ramezani M, Yazdian-Robati R, Alibolandi M, Taghdisi S M. Nanomedicine: Nanotechnology, Biology, and Medicine, 2017, 13(6): 1933.

[44] Li N, Xiang M H, Liu J W, Tang H, Jiang J H. Analytical Chemistry, 2018, 90(21): 12951.

[45] Li Y, Liu R, Shi Y, Zhang Z, Zhang X. Theranostics, 2015, 5(6): 583.

[46] Ozes A R, Wang Y, Zong X, Fang F, Pilrose J, Nephew K P. Scientific Reports, 2017, 7(1): 894.

[47] Wang S, Sun C, Li J, Zhang E, Ma Z, Xu W, Li H, Qiu M, Xu Y, Xia W, Xu L, Yin R. Cancer Letters, 2017, 408: 112.

[48] Wan J, Geng S, Zhao H, Peng X, Xu J, Wei M, Mao J, Zhou Y, Zhu Q, Zhao Y, Yang X. Nanoscale, 2018, 10(42): 20020.

[49] He B, Wang Y, Shao N, Chang H, Cheng Y. Acta Biomaterialia, 2015, 22: 111.

[50] Fan X, Sun L, Wu Y, Zhang L, Yang Z. Scientific Reports, 2016, 6: 25799.

[51] Matsunaga K, Kimoto M, Hanson C, Sanford M, Young H A, Hirao I. Scientific Reports, 2015, 5: 18478.

[52] Cogoi S, Zorzet S, Rapozzi V, Geci I, Pedersen E B, Xodo L E. Nucleic Acids Research, 2013, 41(7): 4049.

[53] Xie H, Zhan H, Gao Q, Li J, Zhou Q, Chen Z, Liu Y, Ding M, Xiao H, Liu Y, Huang W, Cai Z. Cancer Letters, 2018, 422: 94.

[54] McNamara J O, Kolonias D, Pastor F, Mittler R S, Chen L, Giangrande P H, Sullenger B, Gilboa E. The Journal of Clinical Investigation, 2008, 118(1): 376.

[55] Seo Y E, Suh H W, Bahal R, Josowitz A, Zhang J, Song E, Cui J, Noorbakhsh S, Jackson C, Bu T, Piotrowski-Daspit A, Bindra R, Saltzman W M. Biomaterials, 2019, 201: 87.

[56] Sun Q, Kang Z, Xue L, Shang Y, Su Z, Sun H, Ping Q, Mo R, Zhang C. Journal of the American Chemical Society, 2015, 137(18): 6000.

[57] Durso M, Gaglione M, Piras L, Mercurio M E, Terreri S, Olivieri M, Marinelli L, Novellino E, Incoronato M, Grieco P, Orsini G, Tonon G, Messere A, Cimmino A. European Journal of Medicinal Chemistry, 2016, 111: 15.

[58] Dassie J P, Liu X Y, Thomas G S, Whitaker R M, Thiel K W, Stockdale K R, Meyerholz D K, McCaffrey A P, McNamara J O, Giangrande P H. Nature Biotechnology, 2009, 27(9): 839.

[59] Westerlund K, Vorobyeva A, Mitran B, Orlova A, Tolmachev V, Karlstrom A E, Altai M. Biomaterials, 2019, 203: 73.

[60] Gasparello J, Manicardi A, Casnati A, Corradini R, Gambari R, Finotti A, Sansone F. Scientific Reports, 2019, 9(1): 3036.

[61] Li L, Hu X, Zhang M, Ma S, Yu F, Zhao S, Liu N, Wang Z, Wang Y, Guan H, Pan X, Gao Y, Zhang Y, Liu Y, Yang Y, Tang X, Li M, Liu C, Li Z, Mei X. Molecular Therapy. Nucleic Acids, 2017, 8: 169.

[62] Gupta A, Quijano E, Liu Y, Bahal R, Scanlon S E, Song E, Hsieh W C, Braddock D E, Ly D H, Saltzman W M, Glazer P M. Molecular Therapy. Nucleic Acids, 2017, 9: 111.

[63] Chen W H, Yang S S, Fadeev M, Cecconello A, Nechushtai R, Willner I. Nanoscale, 2018, 10(10): 4650.

[64] Kratschmer C, Levy M. Molecular Therapy. Nucleic Acids, 2018, 10: 227.

[65] Wang K, Yao H, Meng Y, Wang Y, Yan X, Huang R. Acta Biomaterialia, 2015, 16: 196.

[66] He X, Chen X, Liu L, Zhang Y, Lu Y, Zhang Y, Chen Q, Ruan C, Guo Q, Li C, Sun T, Jiang C. Advanced Science, 2018, 5(5): 1701070.

[67] Li L L, Xie M, Wang J, Li X, Wang C, Yuan Q, Pang D W, Lu Y, Tan W. Chemical Communications, 2013, 49(52): 5823.

[68] Yang Y, Liu J, Sun X, Feng L, Zhu W, Liu Z, Chen M. Nano Research, 2015, 9(1): 139.

[69] Kong L, Qiu J, Sun W, Yang J, Shen M, Wang L, Shi X. Biomaterials Science, 2017, 5(2): 258.

[70] Zhan Y, Ma W, Zhang Y, Mao C, Shao X, Xie X, Wang F, Liu X, Li Q, Lin Y. ACS Applied Materials & Interfaces, 2019, 11(17): 15354.

[71] Taghavi S, Ramezani M, Alibolandi M, Abnous K, Taghdisi S M. Cancer Letters, 2017, 400: 1.

[72] Yuan Q, Wu Y, Wang J, Lu D, Zhao Z, Liu T, Zhang X, Tan W. Angewandte Chemie, 2013, 52(52): 13965.

[73] Pi F, Zhang H, Li H, Thiviyanathan V, Gorenstein D G, Sood A K, Guo P. Nanomedicine: Nanotechnology, Biology, and Medicine, 2017, 13(3): 1183.

[74] Ma Y, Zhao W, Li Y, Pan Y, Wang S, Zhu Y, Kong L, Guan Z, Wang J, Zhang L, Yang Z. Biomaterials, 2019, 197: 182.

[75] Bertucci A, Prasetyanto E A, Septiadi D, Manicardi A, Brognara E, Gambari R, Corradini R, de Cola L. Small, 2015, 11(42): 5687.