Green and Efficient Synthesis of 3-Pyrazolyl Indoles in Water

Abstract

A green and efficient synthesis of 3-pyrazolyl indoles was developed by the cyclocondensation reaction of β-ethylthio-β-indolyl-α, β-unsaturated ketones with semicarbazide hydrochloride as hydrazine equivalent in the presence of 3 equiv. of PEG-400(1a/PEG mole ratio of 1:3) in reflux water. This procedure did not require toxic hydrazine and product purification, eliminating the use of toxic liquid chemicals.

Keywords

3-Pyrazolyl indole / Green synthesis / Semicarbazide hydrochloride / Polyethylene glycol / Hydrazine equivalent

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