Dissipative Particle Dynamics Study on Platycodin’s Solubilization Enhancing Effect Towards Five Drug Components

Abstract

In this study, a dissipative particle dynamics mehtod was used to study the solubilization enhancing effect of platycodin towards 5 different drug components. Two factors were mainly considered, including the XlogP value of drug components and the sugar chain length of platycodin. As a result, it was found that there was an optimal drug XlogP value for the solubilization enhancing effect of platycodin, and it was different between the drug’s own XlogP value and the optimal drug XlogP value of platycodin that determines the solubilization enhancing effect.

Keywords

Platycodin / Dissipative particle dynamics / Solubilization enhancing effect / XlogP

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