A Highly Efficient and Recyclable Solid Acid Catalyst for Synthesis of Spiro-oxindole Dihydroquinazolinones Under Ultrasound Irradiation

Abstract

A simple, efficient and green procedure for the synthesis of spiro-oxindole dihyfroquinazolinones was developed by multi-component condensation of isatoic anhydride, aniline and isatin in the presence of a novel solid acid catalyst under ultrasound irradiation. The present environmentally benign protocol offers several advantages, such as shorter reaction time, a wide range of functional group tolerance, the use of an inexpensive heterogeneous catalyst, and a high yield of products via a simple experimental and work-up procedure. The mesoporous solid acid catalyst was directly prepared from phytic acid by microwave-sulfonation method without template. The phytic acid based solid acid was fully characterized by means of Fourier transform infrared spectroscopy(FTIR), Raman spectroscopy, X-ray diffraction(XRD), X-ray photoelectron spectroscopy(XPS), and transmission electron microscopy(TEM). The catalyst can be recovered and reused for at least five runs without significant impact on the product yields.

Keywords

Microwave-sulfonation method / Solid acid catalyst / Spiro-oxindole dihyfroquinazolinone

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