CuCl₂/8-Hydroxyquinoline-catalyzed α-Arylation of Diethyl Malonate with Aryl Bromides

Abstract

A general and efficient coupling of aryl bromides with diethyl malonate is presented. The reaction provided the α-arylated diethyl malonates in moderate to good yields with a low loading of CuCl₂(5%, molar fraction) and 8-hydroxyquinoline(5%, molar fraction). This method has good compatibility for a wide range of aryl bromides.

Keywords

Copper catalyst / α-Arylation / Malonate / Ullmann reaction / Hurtley reaction

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