Synthesis and antibacterial activity of oxazolidinone derivatives containing nitro heteroaromatic moiety

Abstract

A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of ¹H NMR and MS spectra. All target compounds were evaluated for their in vitro antibac-terial activities against S.au 29213, methicillin-resistant Staphylococcus aureus(MRSA) and vancomycin-resistant Enterococcus(VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S.au 29213, MRSA and VRE. Among them, compounds 10e and 10f displayed better activity than the control.

Keywords

Oxazolidinone derivative / Antibacterial activity / Linezolid / Ranbezolid

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