Studies on the activities of electrophilic sites on benzene ring of 4-substituted anilines and their acyl compounds with multiphilicity descriptor

Abstract

In this paper, the activities of electrophilic sites on benzene ring of 4-substituted anilines and their acyl compounds were studied with the quantitative indicator of multiphilicity descriptor. Four substituents were synthesized with microwave irradiation in good yields to verify the quantitative analysis data. Friedel-Crafts acylation was carried out by the microwave method for the first time.

Keywords

Quantum chemical calculation / Electrophilic site / Multiphilicity descriptor / Benzodiazepine / Electrophilic substitution reaction

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