Two new baccharane glycosides from seeds of Impatientis balsamina L. with in vitro growth inhibitory activity in human cancer A375 cells

Abstract

Two new baccharane-type glycosides (1 and 2), together with seven known baccharane-type glycosides (3―9) hosenkoside A, hosenkoside B, hosenkoside C, hosenkoside F, hosenkoside M, hosenkoside K and hosenkoside G were isolated from the dried seeds of Impatientis balsamina L. The new baccharane-type glycosides were identified as honsenkol A-3-O-β-D-glucopyranosyl-26-O-β-D-glucopyranosyl-28-O-β-D-glucopyranosyl-O-β-D-glucopyranosyl(1) and (3S,4R,17R,20S)-17-hydroxy-3-O-β-D-xylopyranose(12)-β-D-glucopyranosyl-26-O-β-D-glucopyranosyl-28-O-β-D-glucopyranosyl-21,24-epoxybaccharane(2), respectively, by spectroscopic methods, including NMR(1D and 2D), IR and HR-ESI-MS. Compounds 1 and 2 were evaluated for in vitro inhibitory activity against the cell lines. Compound 2 with a new baccharane skeleton had anti-hepatic fibrosis activity against A375 cells in bioassay results, which means the new compounds have potential value in antitumor applications.

Keywords

Impatientis balsamina L. / Seed / Baccharane-type glycoside / Cytotoxic activity

References

[1] Li H. J., Yu J. J., Li P. J. Pharm. Biomed. Anal., 2011, 54(4): 674.

[2] Li Q. G., Hu D. M., Li Y. F. China Pharm., 2012, 2: 262.

[3] Lei J., Qian S. H., Jiang J. Q. J.Asian Nat. Prod. Res., 2010, 12(12): 1033.

[4] Shoji N., Umeyama A., Taira Z., Takemoto T., Nomoto K., Mizuka-wa K., Ohizumi Y. J. Chem. Soc. Chem. Commun., 1983, 16(16): 871.

[5] Shoji N., Umeyama A., Yoshikawa K., Kan Y., Arihara S. Tetrahe-dron, 1994, 50(17): 4973.

[6] Shoji N., Umeyama A., Saitou N., Yoshikawa K., Nagai M., Arihara S. Chem. Pharm. Bull., 1994, 42(7): 1422.

[7] Shoji N., Umeyama A., Saitou N., Yoshikawa K., Nagai M., Arihara S. Phytochemistry, 1994, 37(37): 1437.

[8] Tan L. N., Lu J., Zhu N., Chin J. Pharm. Anal., 2009, 29(5): 717.

[9] Meng L., Li Q. M., Tong Y. N., Jin Y. R. J. Jilin University Sci. Ed., 2011, 49(5): 951.

[10] Lei J., Qian S. H., Jiang J. Q. J. China Pharm.Univ., 2010, 41(2): 118.

[11] Chen M. X., Wang X. L., Zhang Y. J. Chin. Mat. Med., 2006, 31(11): 928.

[12] Rumampuk R. J., Pongoh E. J., Tarigan P., Herlt A. J., Mander L. N. Indones. J. Chem., 2010, 3(3): 149.

[13] Zhou X. F., Zhao X. Y., Tang L., Ruan H. L., Zhang Y. H., Pi H. F., Wu J. Z. J. Asian Nat. Prod. Res., 2007, 9(4): 379.

[14] Motz V. A., Bowers C. P., Kneubehl A. R., Lendrum E. C., Young L. M., Kinder D. H. J. Ethnopharmacol., 2015, 162(4): 163.

[15] Motz V. A., Bowers C. P., Young L. M., Kinder D. H. J. Ethnophar-macol., 2012, 143(1): 314.

[16] Pavela R., Vrchotová N., Será B. Biopesticides, 2009, 2(1): 48.

[17] Yang J., Yu X., Chen Y. X., Zhang H. M., Li X. W., Jin Y. R. Chem. Res. Chinese Universities, 2016, 32(1): 35.

[18] Li M., Jin Y. R., Wang X. Z., Wu Q., Liu Y., Li P. Chem. Res. Chinese Universities, 2016, 32(6): 943.