Functionalization of magnetic titanium dioxide for targeted drug delivery and UV-induced release

Abstract

Magnetic titanium dioxide core-shell nanoparticles(Fe₃O₄@TiO₂ NPs) were synthesized as particles with appropriate size for intravenous injection. They subsequently were functionalized with p-aminothiophenol(PATP) to facilitate the covalent attachment of target drugs through azo coupling reaction, which can be universally observed in a variety of drugs containing phenols, anilines, and imidazoles. The proposed drug nanocarrier was designed to possess the ability to release drugs upon UV irradiation because of the photocatalytic property of the TiO₂ shells. All the results indicate the potential application of the Fe₃O₄@TiO₂ NPs in targeted drug delivery with greater chemical sta-bility and universality.

Keywords

Magnetic titanium dioxide / Targeted drug delivery / Azo coupling

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