Potassium tert-Butanolate promoted reaction of benzaldehydes and indoles: a new strategy for synthesis of bis(indolyl)arylmethanes

Abstract

t-BuOK-promoted synthesis of bis(indolyl)arylmethanes from aromatic aldehydes and indoles is achieved. Substrates bearing different functional groups, especially groups which are sensitive to acidic media, are well tole-rated under the optimal condition, making this reaction particularly attractive for expanding the scope of the present protocols that provides bis(1H-indol-3-yl)arylmethanes.

Keywords

Bis(indolyl)arylmethane / Indole / Base-promoted reaction

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