Studies on triterpenoid glycosides from rhizomes of Panacis majoris and their antiplatelet aggregation activity

Abstract

A new triterpenoid glycoside(1) and seven known triterpenoid glycosides, pseudoginsenoside RT₂(2), yesanchinoside R₂(3), vinaginsenoside R13(4), vinaginsenoside R8(5), notoginsenoside E(6), 6′′′-O-acetylginsenoside Re(7), 6″-O-acetylginsenoside Rb₁(8), were isolated from the rhizomes of Panacis majoris. The new triterpenoid glycoside was elucidated as 3-O-[β-D-glucopyranosyl-(1→2)-β-D-(6′-O-ethyl)-glucuronopyranosyl]-oleanolic acid-28-O-β-D-glucopyranoside by extensive spectroscopic and phytochemical methods. Compounds 2―8 were obtained from the plant for the first time. Compounds 3 and 4 displayed good activities against adenosine diphosphate (ADP)-induced platelet aggregation, and compounds 1, 5, 6 and 8 showed moderate activities. Compound 6 exhibited moderate antiplatelet aggregation activity induced by arachidonic acid(AA).

Keywords

Panacis majoris / Rhizome / Triterpenoid glycoside / Antiplatelet aggregation

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