Facile synthesis of unsymmetrical N-aryl-2,2-di(1H-indol-3-yl) acetamide derivatives

Yan Zhou; Renjun Li; Xiaolong Wang; Ling He; Mei Guan; Yong Wu

doi:10.1007/s40242-016-6233-0

Chemical Research in Chinese Universities ›› 2016, Vol. 32 ›› Issue (6) : 959 -966. DOI: 10.1007/s40242-016-6233-0

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Facile synthesis of unsymmetrical N-aryl-2,2-di(1H-indol-3-yl) acetamide derivatives

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Abstract

A facile and highly efficient method has been developed for the synthesis of unsymmetrical N-aryl-2,2-di(1H-indol-3-yl)acetamide derivatives by regioselective Friedel-Crafts alkylation of the N-aryl-2-hydroxy-2-(1H-indol-3-yl) acetamide derivatives with various indoles catalyzed by 2 mol/L H₂SO₄ at room temperature in a short reaction time, the yield was up to 94%.

Keywords

N-Aryl-2,2-di(1H-indol-3-yl)acetamide derivative / Indole / Unsymmetry / Friedel-Crafts alkylation / Brønsted acid

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Yan Zhou, Renjun Li, Xiaolong Wang, Ling He, Mei Guan, Yong Wu. Facile synthesis of unsymmetrical N-aryl-2,2-di(1H-indol-3-yl) acetamide derivatives. Chemical Research in Chinese Universities, 2016, 32(6): 959-966 DOI:10.1007/s40242-016-6233-0

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