Efficient synthesis of beraprost sodium

Abstract

An efficient and straightforward synthesis of beraprost sodium has been developed with dicyclopentadiene as a starting material, a one-pot reaction product 5 as key intermediate and the Prins reaction and the Horner-Wadsworth-Emmons reaction as key steps. The structures of key intermediate and target compound were confirmed by ¹H NMR, ¹³C NMR and MS. The purity of beraprost sodium identified by high performance liquid chromatography(HPLC) was identical to that of Japanese Pharmacopoeia(16^th). This development will be used for the industrial synthesis of beraprost sodium.

Keywords

Beraprost sodium / One-pot reaction / Prins reaction / Horner-Wadsworth-Emmons reaction

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