Zirconium-mediated selective synthesis of quinoline derivatives

Abstract

A series of quinoline derivatives was obtained in high yields by an efficient one-pot reaction of substituted o-diiodobenzenes with azazirconacyclopentadienes, which were conveniently prepared from one internal alkyne and one nitrile mediated by zirconocene. This proposed synthetic method provides a feasible way to the synthesis of large N-heterocyclic π-conjugated molecules.

Keywords

Azazirconacyclopentadiene / One-pot reaction / Quinoline derivatives / Zirconocene

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