Regioselective synthesis of functionalized dihydroquinolines via organocatalytic allylic alkylation

Abstract

The regioselective allylic alkylation of 1,2-dihydroquinolines and Morita-Baylis-Hillman(MBH) adducts has been developed. By surveying various reaction parameters, we summarize the effects of temperatures, relative reactant doses, catalysts, solvents and N-protected groups on the regioselectivity of this transformation. This method provides a facile protocol for the preparation of allylic α-substituted dihydroquinolines.

Keywords

1,2-Dihydroquinoline / Regioselectivity / Allylic alkylation

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