Cuprous oxide/nitrogen-doped graphene nanocomposites as electrochemical sensors for ofloxacin determination

Abstract

Cu₂O/nitrogen-doped grapheme(NG) nanocomposite material was prepared via a facile one step chemical reduction and characterized by means of X-ray diffraction(XRD) and scanning electron microscopy(SEM). A new electrochemical sensor was then fabricated by coating Cu₂O/nitrogen-doped graphene nanocomposite with Nafion on glassy carbon electrode(Cu₂O/NG/Nafion/GCE). The electrochemical response of this modified electrode toward ofloxacin was examined by cyclic voltammetry. The results indicate that Cu₂O/NG/Nafion composite-modified electrode exhibits higher catalytic activity in the electrochemical oxidation of ofloxacin compared with glassy carbon electrode(GCE), Cu₂O/Nafion modified electrode(Cu₂O/Nafion/GCE), and N-doped graphene/Nafion modified electrode( NG/Nafion/GCE). Under optimal conditions, the peak current was found to be linearly proportional to the concentration of ofloxacin in the 0.5―27.5 μmol/L and 27.5―280 μmol/L ranges with a lower detection limit of 0.34 μmol/L, higher sensitivity of 39.32 μA·L·mmol^–1 and a shorter reaction time of less than 2 s. In addition, Nafion can enhance the stability of the modified electrode and prevent some negative species. Thus the modified electrode exhibits good selectivity and a long working life. The Cu₂O/NG/Nafion composite modified electrode shows promising application in electrochemical sensors, biosensors, and other related fields because of its excellent properties.

Keywords

Cu₂O / Nitrogen-doped graphene / Ofloxacin / Electrochemical method / Determination

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