Synthesis and bioactivity of a novel bismuthoxide Schiff-base complex derived from Salen-like ligand and bismuth(III) nitrate

Abstract

In this paper, a novel bismuthoxide Schiff-base complex [Bi₉O₈(vanen)₃(NO₃)₂(CH₃OH)₂(H₂O)·3NO₃·5.5H₂O](abbreviated as Bivanen) was synthesized with Salen-like ligand[H₂vanen=N,N’-ethylene bis(3-methoxy-salicylideneimine)] and bismuth(III) nitrate. Its structure was characterized by IR spectra, NMR spectra and X-ray diffraction. In particular, the biology activities of the ligand and the complex against Schizosaccharomyces pombe (S. pombe) were studied using biological microcalorimetry. The metabolic thermogenic curves of S. pombe were measured at 32.00 °C. Then, some quantitative thermokinetic parameters of growth metabolism of S. pombe including the rate constant(k), inhibition ratio(I) and half inhibition concentration(IC₅₀) were calculated. Experimental results showed that the k values of S. pombe decreased while I values of S. pombe increased with the increase of concentrations of the ligand and the complex. The IC₅₀ of the ligand and the complex were found to be 0.067 and 0.037 mmol/L, respectively.

Keywords

Bismuth Schiff-base complex / Microcalorimetriy / Thermokinetic property / Schizosaccharomyces pombe(S. Pombe)

References

[1] Guo Z., Sadler P. J. Angew. Chem. Int. Ed., 1999, 38: 1512.

[2] Thompson K. H., Orvig C. Science, 2003, 300: 936.

[3] Suerbaum S., Michetti P. New Engl. J. Med., 2003, 347: 1175.

[4] Sox T. E., Olsen C. A. Antimicrob. Agents Chemother., 1989, 33: 2076.

[5] Slikkerveer A., de Wolff F. A. Med. Toxicol. Adverse Drug Exp., 1989, 4: 303.

[6] Graham D. Y., Lew G. M., Evans D. G., Klein P. D. Ann. Intern. Med., 1991, 115: 266.

[7] Chiba N. Can. J. Gastro., 2000, 14: 885.

[8] Houghton J., Fox J. G., Wang T. C. Eur. J. Gastroenterol. Hepatol., 2002, 17: 495.

[9] Marchi S., Costa F., Bellini M., Belcari C., Mumolo M. G., Tornar A., Spisni R., Torelli E., Maltinti G. Eur. J. Gastroenterol. Hepatol., 2001, 13: 547.

[10] Andrews P. C., Deacon G. B., Forsyth C. M., Junk P. C., Kumar I., Maguire M. Angew. Chem. Int. Ed., 2006, 45: 5638.

[11] Thurston J. H., Marlier E. M., Whitmire K. H. Chem. Commun., 2002, 23: 2834.

[12] Burford N., Eelman M. D., Cameron T. S. Chem. Commun., 2002, 13: 1402.

[13] Andrews P. C., Deacon G. B., Jackson W. R., Maguire M., Scott N., Skelton B. W., White A. H. J. Chem. Soc. Dalton Trans., 2002, 24: 4634.

[14] Thurston J. H., Whitmire K. H. Inorg. Chem., 2002, 41: 4194.

[15] Kong W. J., Zhao Y. L., Xing X. Y., Ma X., Sun X. J., Yang M. H., Xiao X. H. Appl. Microbiol. Biotechnol., 2015, 99: 6049.

[16] Wu Y. W., Gao W. Y., Xiao X. H., Liu Y. Thermochim. Acta, 2005, 429: 167.

[17] Cortes J. C., Carnero E., Ishiguro J., Sánchez Y., Durán A., Ribas J. C. J. Cell. Sci., 2005, 118: 157.

[18] Li Q. G., Yang D. J., Li X., Ye L. J., Wei D. L., Xiao S. X. Acta Chim. Sinica, 2008, 66(24): 2686.

[19] Li X., Li Q. G., Zhang H., Hu J. L., Yao F. H., Yang D. J., Xiao S. X., Ye L. J., Huang Y., Guo D. C. Biol. Trace Elem. Res., 2012, 147: 366.

[20] Li X., Jiang J. H., Chen Q., Xiao S. X., Li C. H., Gu H. W., Zhang H., Hu J. L., Yao F. H., Li Q. G. Eur. J. Med. Chem., 2013, 62: 605.

[21] Aguiari A., Bullita E., Casellato U., Guerriero P., Tamburini S., Vigato P. A., Russo U. Inorg. Chim. Acta, 1994, 219: 135.

[22] Ruiz-Martínez A., Casanova D., Alvarez S. Dalton Trans., 2008, 19: 2583.