Synthesis of 5-(sulfamoylmethyl)indoles by mild Negishi coupling and their application in almotriptan

Abstract

A new synthetic route of almotriptan was described. The application of Negishi coupling reaction simplified the process and significantly improved the yield. The synthetic route was also expected to be general for the synthesis of other tryptamines like sumatriptan and avitriptan.

Keywords

Negishi coupling / Almotriptan / 5-(Sulfamoylmethyl)indole

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