Solvent-free 1,3-dipolar cycloaddition of azomethine imines with terminal alkynes promoted by calcium fluoride under the ball milling condition

Abstract

A convenient and efficient procedure for the synthesis of N,N-bicyclic pyrazolidinone derivatives has been developed via the reaction of azomethine imines with terminal alkynes under the ball milling condition without solvent, which was promoted by calcium fluoride with a catalyst of copper(I) salt. The cyclization reactions exhibited moderate to high yields.

Keywords

Ball-milling / 1,3-Dipolar cycloaddition / Click chemistry / Solvent-free reaction

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