Efficient synthesis of α-amino acid derivatives via phase-transfer-catalyzed directed reductive amination

Abstract

An efficient phase-transfer-catalyzed directed reductive amination of α-keto esters was described using simple substituted benzyl amines as nitrogen source and K₂CO₃ as base at room temperature, giving a series of aliphatic α-amino acid derivatives in moderate to high yields(up to 99%). Preliminary study on this asymmetric process showed that cinchona-derived phase transfer catalyst was effective, affording the corresponding product in 13% e.e. and 40% yield.

Keywords

Directed reductive amination / α-Amino acid / Phase transfer catalyst

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