One-pot three-component reaction for efficient and facile synthesis of γ-nitrocarbonyl compounds under solvent-free conditions

Chengwei Lü; Yanhang Liu; Xiaoxia Zhou; Jiajing Wang

doi:10.1007/s40242-015-4410-1

Chemical Research in Chinese Universities ›› 2015, Vol. 31 ›› Issue (2) : 208 -211. DOI: 10.1007/s40242-015-4410-1

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One-pot three-component reaction for efficient and facile synthesis of γ-nitrocarbonyl compounds under solvent-free conditions

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Abstract

A simple and efficient protocol was established to synthesize γ-nitrocarbonyl compounds via three-component one-pot tandem condensation reaction of aldehydes, Meldrum’s acid and nitroalkanes under solvent-free conditions. The present method shows fascinating features such as using readily available starting materials, promoting the yields by inexpensive and mild organic base triethylamine, omiting the synthesis of Michael acceptor and avoiding the use of organic solvent. This strategy provides an easy alternative synthetic approach to the useful intermediate, γ-nitrocarbonyl compounds, with moderate to good yields.

Keywords

γ-Nitrocarbonyl compound / Multicomponent reaction / One-pot reaction / Solvent free

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Chengwei Lü, Yanhang Liu, Xiaoxia Zhou, Jiajing Wang. One-pot three-component reaction for efficient and facile synthesis of γ-nitrocarbonyl compounds under solvent-free conditions. Chemical Research in Chinese Universities, 2015, 31(2): 208-211 DOI:10.1007/s40242-015-4410-1

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