An efficient and green approach to synthesizing enamines by intermolecular hydroamination of activated alkynes

Abstract

An efficient, atom-economic and green approach to synthesizing enamines was developed by intermolecular hydroamination of activated alkynes with high yields under catalyst- and solvent-free conditions. β-Dimethylamino-acrylate derivatives were also obtained with high yields. In the synthetic process of the derivatives, N,N-dimethylformamide(DMF) pretreated with metal Na, was used as reactant instead of dimethylamine gas. The proposed synthetic method can be used for the synthesis of (E)-ethyl-3-(dimethylamino)acrylate(3cl), and provide a new possible way to the synthesis of Quinolones.

Keywords

Enamine / Hydroamination / Activated alkyne / Catalyst-free / Solvent-free / N,N-Dimethylformamide

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