Indole-tolerant oxidation of 1,2-diarylalkynes to 1,2-diketone derivatives

Abstract

A new indole-tolerant oxidation condition for the synthesis of 1,2-diketone derivatives from the corresponding 1,2-diarylalkynes was described. By screening a series of oxidation systems on alkynes linked with indole and different substituted aromatic ring, the DMSO/PdCl₂/CuCl₂ system afforded moderate to good yields despite the existence of electron-rich indole ring.

Keywords

Selective oxidation / 1,2-Diarylalkyne / 1,2-Diketone

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