Synthesis and characterization of novel azo-containing or azoxy-containing Schiff bases and their antiproliferative and cytotoxic activities

Abstract

A series of novel Schiff base derivatives was designed and synthesized from 3,3′-azobenzaldehyde and 3,3′-azoxybenzaldehyde. The newly synthesized compounds were characterized by FTIR, ¹H NMR, MS and elemental analysis and tested for their in vitro antiproliferative activities against HeLa cell lines. At the same time, the impact on the antitumor activity of the sulfanilamido, benzamido, phenolic hydroxyl or thiourea groups was investigated and discussed. Compounds 4, 6 and 10 were found to exhibit strong cytotoxic activity.

Keywords

Schiff base / Azo / Azoxy / Anti-proliferative activity / Cytotoxic activity

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