One-step synthesis of 5-ethyl-2-methylpyridine from NH₄HCO₃ and C₂H₅OH under hydrothermal condition

Abstract

A simple one-pot approach to synthesizing 5-ethyl-2-methylpyridine(EMP) was established using NH₄HCO₃ and C₂H₅OH as starting materials and commercial Cu₂O as catalyst and oxidant under hydrothermal condition. Different reaction conditions were researched and the optimal ones were achieved by studying the parameters, that could affect the yield of product and by considering the energy and resource saving. The present study provided an eco-friendly way to obtaining EMP with lower volatility using fewer toxic starting materials.

Keywords

5-Ethyl-2-methylpyridine / Hydrothermal condition / NH₄HCO₃ / C₂H₅OH / Cu₂O

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