Synthesis of resveratrol analogs/stilbene derivatives and their nitric oxide inhibitory and radical scavenging activities

Abstract

Sixteen resveratrol analogs(stilbene derivatives) including resveratrol were synthesized, in which hydroxystilbenes, naturally occurring polyphenols, showed protective effects against reactive oxygen and nitrogen species(ROS/RNS) and hexahydroxystilbene(16) displayed the strongest activities against NO and 1,1-diphenyl-2-picrylhydrazyl(DPPH) with IC₅₀ values of 7.8 and 5.7 μmol/L, respectively.

Keywords

Resveratrol / Stilbene / Nitric oxide / Radical

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