Electrochemical reaction mechanism of phenacetin at a carboxylated multiwall carbon nanotube modified electrode and its analytical applications

Abstract

A novel type of carboxylated multiwalled carbon nanotube modified electrode(c-MWCNTs/GCE) was constructed and the electrochemical properties of phenacetin(PHE) at it were studied. In a buffer solution of 0.1 mol/L HAc-NaAc(pH=5.3), PHE exhibited a couple of quasi-reversible redox peaks and an anodic peak in the potential range of 0.2–1.2 V at c-MWCNTs/GCE. The peak current was proportional to the concentration of PHE in the range of 4.0×10⁻⁶–1.0×10⁻⁴ mol/L with a detection limit of 1.0×10⁻⁶ mol/L(S/N=3). The c-MWCNTs/GCE showed excellent repeatability and stability and the electrochemical reaction mechanism of PHE was proposed. This method was used to determine the content of PHE in medical tablets and the recovery was determined to be 96.5%–104.2% by means of a standard addition method.

Keywords

Carboxylated multiwalled carbon nanotube / Modified electrode / Phenacetin

References

[1] Iijima S. Nature, 1991, 354: 56.

[2] Dresselhaus M S, Dresselhaus G, Eklund P. Science of Fullerenes and Carbon Nanotubes, 1996, New York: Academic Press 461.

[3] Arvinte A, Westermann A C, Sesay A M, Virtanen V. Sensor Actuat. B: Chem., 2010, 150: 756.

[4] Desai P B, Srivastava A K. Sensor Actuat. B: Chem., 2012, 169: 341.

[5] Rosa O M, Ana P, Jordi B, Mireia B, Francisco C. Talanta, 2010, 81: 1593.

[6] Guo Y J, Guo S J, Fang Y X, Dong S J. Electrochim. Acta, 2010, 55: 3927.

[7] Zhang J L, Tan X C, Zhao D D, Tan S W, Huang Z W, Mi Y, Huang Z Y. Electrochim. Acta, 2010, 55: 2522.

[8] Kankuri E, Solatunturi E, Vapaatalo H. Thromb. Res., 2003, 110: 299.

[9] Otsuka M. Powder Technol., 2004, 141: 244.

[10] Xu J L, Huang P, Zhang H. Chin. J. Anal. Chem., 2006, 34: 231.

[11] Jan J, Jiří K, Lucia Z Z, Josef T. J. Pharmaceut. Biomed., 2010, 52: 557.

[12] El-Kommos M E, Emara K M. Talanta, 1989, 36: 678.

[13] Eberhart S T, Hatzis A, Rothchild R. J. Pharmaceut. Biomed., 1986, 4: 147.

[14] Liu X Z, Liu S S, Wu J F, Fang Z L. Anal. Chim. Acta, 1999, 392: 273.

[15] Song Y, Deng Y, Huang D X, Wen J, Liu Z G, Li F M. J. Ethnopharmacol., 2012, 141: 957.

[16] Yin H S, Meng X M, Xu Z N, Chen L J, Ai S Y. Anal. Methods, 2012, 4: 1445.

[17] Bian C L, Zeng Q X, Xiong H Y, Zhang X H, Wang S F. Bioelectrochemistry, 2010, 79: 1.

[18] Laviron E. J. Electroanal. Chem., 1974, 52: 355.

[19] Eslam N N, Rainer B, Andries P B, Hjalmar P P. Analyst, 2011, 136: 5064.

[20] Ugo B, Patrick G, Virginie S, Titouan J L, Véronique F R, Michel K, Serge A, Illa T, Mohammed B. Anal. Bioanal. Chem., 2013, 405: 5817.

[21] Ugo B, Patrick G, Illa T, Mohammed B. Talanta, 2013, 116: 554.