Stereoselective synthesis of (R)-salmeterol via asymmetric cyanohydrin reaction

Abstract

The authors described a short and highly enantioselective route to (R)-salmeterol involving asymmetric synthesis of cyanohydrin followed by nucleophilic substitution with 6-(4-phenylbutoxy) hexyl methanesulfonate.

Keywords

Asymmetric synthesis / Catalysis / Cyanohydrin / Ethanolamine / Methanesulfonate

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