Enzymatic promiscuity: “Amano” lipase AS-catalysed synthesis of naphthopyran derivatives in anhydrous media

Abstract

“Amano” lipase AS(lipase from Aspergillus niger), which naturally hydrolyzes triglycerides, was found promiscuously to catalyze multi-component reactions of aromatic aldehydes with malononitrile and β-naphthol to prepare naphthopyran derivatives in anhydrous organic solvents in moderate to good yields.

Keywords

“Amano” lipase AS / Catalytic promiscuity / Multi-component reaction / Naphthopyran derivative

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