Synthesis and herbicidal activities of novel uracil derivatives containing pyrimidinyl moiety

Leien He; Yingying Wu; Hanyun Zhang; Manyun Liu; Deqing Shi

doi:10.1007/s40242-014-3439-x

Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (3) : 400 -404. DOI: 10.1007/s40242-014-3439-x

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Synthesis and herbicidal activities of novel uracil derivatives containing pyrimidinyl moiety

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Abstract

In order to find novel protoporphyrinogen oxidase inhibitors with high efficacy, broad-spectrum activity, and safety to crops, nine title compounds(4a–4i) were designed and synthesized by introducing pyrimidine moiety into the uracil skeleton with commercially herbicide butafenacil as the lead compound. Their structures were confirmed by ¹H NMR, IR, mass spectroscopy and elemental analysis. The bioassay results indicate that most of compounds 4 tested exhibit good to excellent herbicidal activities against B. campestris, A. retroflexus, E. crusgalli and D. sanguinalis in pre-emergence treatment at a dose of 1.5 kg/ha(1 ha=10⁴ m²), for example, compound 4i showed 100% inhibition against the four plants tested in pre-emergence treatment at a dose of 1.5 kg/ha. So, this type of skeleton can be used as a valuable lead compound for the further development of a pre-emergent herbicide.

Keywords

Protoporphyrinogen oxidase / Uracil / Pyrimidine / Herbicidal activity

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Leien He, Yingying Wu, Hanyun Zhang, Manyun Liu, Deqing Shi. Synthesis and herbicidal activities of novel uracil derivatives containing pyrimidinyl moiety. Chemical Research in Chinese Universities, 2014, 30(3): 400-404 DOI:10.1007/s40242-014-3439-x

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