Ternary solid nano organic/inorganic composite of lanthanum with acetic acid and curcumin/hydroxyapatite and its antibacterial activity

Abstract

Ternary solid complex was synthesized via hybridization of curcumin(Cur), hydroxyapatite(HAP), lanthanum( La) and acetic acid(HAc). The nano-scale hybrid composite of La-Cur/HAP was directly prepared by the wet method. The morphologies and structures of the composite were characterized by scanning electron microscopy (SEM), infrared(IR) spectroscopy, X-ray diffraction(XRD), transmission electron microscopy(TEM) and energy dispersive X-ray spectroscopy. The antibacterial activities were tested by methods of minimum inhibitory concentration (MIC) and minimum bactericidal concentration(MBC). The results show that the size of the La-Cur/HAP composite is less than 100 nm, and the composite exhibits strong bacteriostatic activity against Escherichia coli(E. coli) and Staphylococcus aureus(S. aureus) at low concentrations(in the range of 26–92 μg/mL). The composite can exhibit both of the bacteria and shows higher antibacterial activity against S. aureus than against E. coli. At the same time, La-Cur/HAP shows stronger antibacterial efficiency than ampicillin/HAP.

Keywords

Curcumin / Lanthanum / Hydroxyapatite / Antibacterial activity

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