Interactions of phenanthroline compounds with i-motif DNA

Ning Gao; Yanbo Wang; Chunying Wei

doi:10.1007/s40242-014-3391-9

Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (3) : 495 -499. DOI: 10.1007/s40242-014-3391-9

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Interactions of phenanthroline compounds with i-motif DNA

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Abstract

The interactions of each of three phenanthroline derivatives 1, 2 and 3 with the human telomeric i-motif DNA were investigated. The results suggest these compounds are potent binders. The compounds could stabilize the structure of i-motif DNA by π-π stacking. Moreover, the binding constants of the compounds with i-motif DNA were (2.71–8.12)×10⁴ L·mol⁻¹, and the binding stoichiometry ratio was 1:1. CD studies reveal that the binding by phenanthroline compounds perturbs the conformation of i-motif DNA.

Keywords

i-Motif DNA / Phenanthroline derivative / Interaction

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Ning Gao, Yanbo Wang, Chunying Wei. Interactions of phenanthroline compounds with i-motif DNA. Chemical Research in Chinese Universities, 2014, 30(3): 495-499 DOI:10.1007/s40242-014-3391-9

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