Synthesis and release behavior of a hybrid of camptothecin intercalated dodecyl sulfate modified layered double hydroxide

Abstract

The intercalation of a non-ionic and poorly water-soluble drug, camptothecin(CPT), into dodecyl sulfate (DS) modified layered double hydroxide(LDH) was carried out via a secondary intercalation method to obtain a CPT-DS-LDH hybrid. The in vitro CPT release eFxaminations from the hybrid show that the hybrid can well control the release of CPT, which indicates that the hybrid is a potential drug controlled-release system. Moreover, the intercalation kinetics of CPT into the DS modified LDH fits for the pseudo-second-order model. And the release kinetic process of CPT from the CPT-DS-LDH hybrid at pH=4.8 can be described with pseudo-first-order model, while that at pH=7.2 can be described with both pseudo-first-order model and pseudo-second-order model. Meanwhile, the release mechanism of CPT from the CPT-DS-LDH hybrid was discussed.

Keywords

Layered double hydroxide(LDH) / Camptothecin / Hybrid / Controlled release

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