A novel coumarin-based fluorescence chemosensor for Fe³⁺

Abstract

A novel coumarin derivative[7-diethylamino-2-oxo-2H-chromene-3-carboxylic acid(6-amino-pyridin-2-yl)-amide, CFe1] has been synthesized and its potential application as a chemosensor for the detection of metal ions has been further investigated. The responses of CFe1 to Fe³⁺ were studied by fluorescence emission spectrometry in the presence of other metal ions such as Al³⁺, Ba²⁺, Ca²⁺, Co³⁺, Cr³⁺, Cu²⁺, Fe²⁺, Hg²⁺, Mg²⁺, Mn²⁺, Na⁺, Ni⁺, Pb²⁺, Zn²⁺, K⁺, and Ag⁺. CFe1 showed a good selectivity for Fe³⁺ with fast response, a wide pH span of 3.3–9.18, and a large Stocks shift. CFe1 in the presence of Fe³⁺ and ethylene diamine tetraacetic acid(EDTA) makes the blue solution fade to colorless, which is due to the formation of CFe1-Fe³⁺ complex instead of any catalytic action of Fe³⁺. Furthermore, the imaging of Fe³⁺ in cultured single mice microglia cells was realized with the aid of CFe1, indicating that CFe1 has a great potential to be used as promising models for the future design of novel and robust chemosensor for metal ion detection in the field of biomedical and environmental analyses.

Keywords

Coumarin / Fe³⁺ / Fluorescence / Selectivity

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