Synthesis of nitroanilines catalyzed by horseradish peroxidase in the presence of NaNO₂ and H₂O₂

Abstract

The synthesis of nitroanilines catalyzed by horseradish peroxidase(HRP) in the presence of sodium nitrite and hydrogen peroxide was investigated. o-Nitroaniline and p-nitroaniline were found in the nitrated products. 2-Aminotoluene and 4-aminotoluene could also be nitrated to give corresponding nitrated products. This protocol has great potentials to open new avenues useful for the synthesis of nitroaniline and its derivatives.

Keywords

Nitroaniline / Horseradish peroxidase / Phenylamine / Nitration / Enzyme

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