Simple and efficient procedure for highly diastereoselective synthesis of trans-1,1-disubstituted-2,6-diarylcyclohexane-4-ones

Abstract

A simple and efficient method has been developed for highly diastereoselective synthesis of trans-1,1-disubstituted-2,6-diarylcyclohexane-4-ones from dibenzalacetone and malononitril with trans-1,2-diaminocyclohexane as catalyst. The substrate 1,5-diaryl-1,4-pentadien-3-ones and active methylene compounds proceeded to give the products with good to excellent yield within a short time.

Keywords

Substituted cyclohexanone / Double Michael addition / Malononitrile

References

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