Design, synthesis and antitumor activity in vitro of a series of 3-arylcoumarins

Abstract

A new series of 7-substituted 3-arylcoumarins was designed, synthesized and evaluated as novel antitumor agents in vitro. It was found that several compounds of them exhibit activity in vitro against SK-HEP-1(hepatocellu- lar carcinoma), HepG2(hepatocellular carcinoma) and SGC7901(gastric carcinoma) cell lines to some extent. Moreover, compounds 5a, 5b, 6a and 6b have better activity against HeLa(cervical carcinoma) cell and their half maximal inhibitory concentration(IC₅₀, μmol/L) values are less than 10.

Keywords

3-Arylcoumarin / Antitumor activity / Structure modification

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