Volume-related efficiency of gadolinium polyoxometalates as MRI contrast agents

Abstract

Two gadolinium polyoxometalates, KCs₄[Gd(α-SiW₁₁O₃₉)]·25H₂O(POM-1) and K₁₃[Gd(β ₂-SiW₁₁O₃₉)₂]· 27H₂O(POM-2), have been evaluated as the candidates of potential magnetic resonance imaging T ₁(longitudinal relaxation) contrast agents. Longitudinal relaxivities of POM-2 are much higher than those of POM-1 in pure water and protein solution, respectively. However, compared with POM-1, POM-2 interacts with protein more strongly through electrostatic interaction, which is comfirmed by the fluoresence quenching of human serum albumin(HSA) in solutions with different polyoxometalate concentrations. Meanwhile, POM-1 presentes much lower cytotoxicity in the cell viability tests.

Keywords

Magnetic resonance imaging(MRI) / Contrast agent / Polyoxometalate

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