cis-nitenpyram analogues bearing acyloxy segments anchored on the tetrahydropyrimidine ring: Synthesis, insecticidal activities and molecular docking studies

Abstract

A series of novel cis-nitenpyram analogues bearing acyloxy segments anchored on the tetrahydropyrimidine ring was designed and synthesized. Preliminary bioassays indicate that all the nitenpyram analogues 3a–3n exhibit good insecticidal activities against Nilaparvata lugens and Aphis medicaginis at 100 mg/L, while analogue 3k affords the best activity in vitro and the lethal concentration 50(LC₅₀) values(0.187, 0.214 mg/L) are close to that of nitenpyram. The structure activity relationships(SARs) suggest that their insecticidal potency is influenced by the species of acyloxy segments. The docking results reveal that analogue 3k forms stronger hydrogen-bonding with the nAChR, which explain the structure activity relationships(SARs) observed in vitro and imply that the strategies of our designed nitenpyram analogues are feasible.

Keywords

cis-Nitenpyram analogue / Acyloxy segment / Hydrogen-bonding action / Insecticidal activity / Molecular docking

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