Anti-diabetic effects of polysaccharides from ethanol-insoluble residue of Schisandra chinensis (Turcz.) Baill on alloxan-induced diabetic mice

Ting Zhao; Guang-hua Mao; Min Zhang; Fang Li; Ye Zou; Ye Zhou; Wei Zheng; Da-heng Zheng; Liu-qing Yang; Xiang-yang Wu

doi:10.1007/s40242-012-2218-9

Chemical Research in Chinese Universities ›› 2013, Vol. 29 ›› Issue (1) : 99 -102. DOI: 10.1007/s40242-012-2218-9

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Anti-diabetic effects of polysaccharides from ethanol-insoluble residue of Schisandra chinensis (Turcz.) Baill on alloxan-induced diabetic mice

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Abstract

The ethanol-insoluble residue of Schisandra generated during lignans industrial production is usually treated as solid waste. However, there is active polysaccharide which could be used in it. In this work, the water-soluble polysaccharides from the ethanol-insoluble residue of Schisandra (ESCP) were obtained and their anti-diabetic effect was evaluated. The results indicate that ESCP could significantly reduce the blood glucose level in alloxan-induced diabetic mice. Moreover, the ESCP could significantly improve the lipid metabolism and increase the content of liver glycogen in alloxan-induced diabetic mice. The results indicate that ESCP could be developed into a potential natural hypoglycemic agent.

Keywords

Schisandra chinensis (Turcz.) Baill / Ethanol-insoluble residue / Polysaccharide / Diabetes mellitus / Hypoglycemic activity

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Ting Zhao, Guang-hua Mao, Min Zhang, Fang Li, Ye Zou, Ye Zhou, Wei Zheng, Da-heng Zheng, Liu-qing Yang, Xiang-yang Wu. Anti-diabetic effects of polysaccharides from ethanol-insoluble residue of Schisandra chinensis (Turcz.) Baill on alloxan-induced diabetic mice. Chemical Research in Chinese Universities, 2013, 29(1): 99-102 DOI:10.1007/s40242-012-2218-9

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