Cell Proliferation >

2024 , Vol. 57 >Issue 4: 0

DOI: https://doi.org/10.1111/cpr.13563

Human midbrain dopaminergic progenitors

  • Yu-Kai Wang 1,2,3,4 ,
  • Lin Feng 1,4,5 ,
  • Ai-Jin Ma 6,7 ,
  • Jie Hao 1,2,3,4,6 ,
  • Ying Zhang 6,8 ,
  • Yue-Jun Chen 9,10 ,
  • Zhi-Guo Chen 11,12 ,
  • Jun-Ying Yu 6,8 ,
  • Yan Liu 13 ,
  • Chang-Mei Liu 1,2,3,5 ,
  • Yu Zhang 6,14 ,
  • Chang-Lin Wang 6,15 ,
  • Zhao-Qian Teng 1,2,3,5 ,
  • Jia-Xi Zhou 6,16 ,
  • Tian-Qing Li 6,17,18 ,
  • Liu Wang 1,2,3,5 ,
  • Bo-Qiang Fu 6,19 ,
  • Yu Vincent Fu 5,20 ,
  • Li-Jun Zhu 6,21 ,
  • Ling-Min Liang 1,4,5,6 ,
  • Jia-Ni Cao 1,2,3,6 ,
  • Lei Wang 1,2,3,4,6 ,
  • Qi Zhou 1,2,3,5,6 ,
  • Andy Peng Xiang , 6,22 ,
  • Bao-Yang Hu , 1,2,3,5 ,
  • Tong-Biao Zhao , 1,2,3,5,6
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  • 1. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
  • 2. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China
  • 3. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
  • 4. National Stem Cell Resource Center, Chinese Academy of Sciences, Beijing, China
  • 5. University of Chinese Academy of Sciences, Beijing, China
  • 6. Chinese Society for Stem Cell Research, Shanghai, China
  • 7. Beijing Technology and Business University, Beijing, China
  • 8. Nuwacell Biotechnologies Co., Ltd., Hefei, China
  • 9. Institute of Neuroscience, Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China
  • 10. Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China
  • 11. Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
  • 12. Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China
  • 13. Institute for Stem Cell and Neural Regeneration, State Key Laboratory of Reproductive Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, China
  • 14. Zephyrm Biotechnologies Co., Ltd., Beijing, China
  • 15. China National Institute of Standardization, Beijing, China
  • 16. Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
  • 17. State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China
  • 18. Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China
  • 19. National Institute of Metrology, Beijing, China
  • 20. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
  • 21. Institute of Scientific and Technical Information of China, Beijing, China
  • 22. Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, China
xiangp@mail.sysu.edu.cn
byhu@ioz.ac.cn
tbzhao@ioz.ac.cn

Received date: 09 Sep 2023

Accepted date: 10 Oct 2023

Copyright

2023 2023 The Authors. Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.
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Abstract

Human midbrain dopaminergic progenitors (mDAPs) are one of the most representative cell types in both basic research and clinical applications. However, there are still many challenges for the preparation and quality control of mDAPs, such as the lack of standards. Therefore, the establishment of critical quality attributes and technical specifications for mDAPs is largely needed. “Human midbrain dopaminergic progenitor” jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research, is the first guideline for human mDAPs in China. This standard specifies the technical requirements, test methods, inspection rules, instructions for usage, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for human mDAPs, which is applicable to the quality control for human mDAPs. It was originally released by the China Society for Cell Biology on 30 August 2022. We hope that the publication of this guideline will facilitate the institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of human mDAPs for clinical development and therapeutic applications.

Cite this article

Yu-Kai Wang , Lin Feng , Ai-Jin Ma , Jie Hao , Ying Zhang , Yue-Jun Chen , Zhi-Guo Chen , Jun-Ying Yu , Yan Liu , Chang-Mei Liu , Yu Zhang , Chang-Lin Wang , Zhao-Qian Teng , Jia-Xi Zhou , Tian-Qing Li , Liu Wang , Bo-Qiang Fu , Yu Vincent Fu , Li-Jun Zhu , Ling-Min Liang , Jia-Ni Cao , Lei Wang , Qi Zhou , Andy Peng Xiang , Bao-Yang Hu , Tong-Biao Zhao . Human midbrain dopaminergic progenitors[J]. Cell Proliferation, 2024 , 57(4) : e13563 . DOI: 10.1111/cpr.13563

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