Human midbrain dopaminergic progenitors

Yu-Kai Wang; Lin Feng; Ai-Jin Ma; Jie Hao; Ying Zhang; Yue-Jun Chen; Zhi-Guo Chen; Jun-Ying Yu; Yan Liu; Chang-Mei Liu; Yu Zhang; Chang-Lin Wang; Zhao-Qian Teng; Jia-Xi Zhou; Tian-Qing Li; Liu Wang; Bo-Qiang Fu; Yu Vincent Fu; Li-Jun Zhu; Ling-Min Liang; Jia-Ni Cao; Lei Wang; Qi Zhou; Andy Peng Xiang; Bao-Yang Hu; Tong-Biao Zhao

doi:10.1111/cpr.13563

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Cell Proliferation ›› 2024, Vol. 57 ›› Issue (4) : e13563. DOI: 10.1111/cpr.13563

PRACTICE INSIGHTS

Human midbrain dopaminergic progenitors

Yu-Kai Wang¹^,²^,³^,⁴ ,
Lin Feng¹^,⁴^,⁵ ,
Ai-Jin Ma⁶^,⁷ ,
Jie Hao¹^,²^,³^,⁴^,⁶ ,
Ying Zhang⁶^,⁸ ,
Yue-Jun Chen⁹^,¹⁰ ,
Zhi-Guo Chen¹¹^,¹² ,
Jun-Ying Yu⁶^,⁸ ,
Yan Liu¹³ ,
Chang-Mei Liu¹^,²^,³^,⁵ ,
Yu Zhang⁶^,¹⁴ ,
Chang-Lin Wang⁶^,¹⁵ ,
Zhao-Qian Teng¹^,²^,³^,⁵ ,
Jia-Xi Zhou⁶^,¹⁶ ,
Tian-Qing Li⁶^,¹⁷^,¹⁸ ,
Liu Wang¹^,²^,³^,⁵ ,
Bo-Qiang Fu⁶^,¹⁹ ,
Yu Vincent Fu⁵^,²⁰ ,
Li-Jun Zhu⁶^,²¹ ,
Ling-Min Liang¹^,⁴^,⁵^,⁶ ,
Jia-Ni Cao¹^,²^,³^,⁶ ,
Lei Wang¹^,²^,³^,⁴^,⁶ ,
Qi Zhou¹^,²^,³^,⁵^,⁶ ,
Andy Peng Xiang⁶^,²² ,
Bao-Yang Hu¹^,²^,³^,⁵ ,
Tong-Biao Zhao¹^,²^,³^,⁵^,⁶

Author information +

¹. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

². Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China

³. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China

⁴. National Stem Cell Resource Center, Chinese Academy of Sciences, Beijing, China

⁵. University of Chinese Academy of Sciences, Beijing, China

⁶. Chinese Society for Stem Cell Research, Shanghai, China

⁷. Beijing Technology and Business University, Beijing, China

⁸. Nuwacell Biotechnologies Co., Ltd., Hefei, China

⁹. Institute of Neuroscience, Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China

¹⁰. Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China

¹¹. Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China

¹². Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China

¹³. Institute for Stem Cell and Neural Regeneration, State Key Laboratory of Reproductive Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, China

¹⁴. Zephyrm Biotechnologies Co., Ltd., Beijing, China

¹⁵. China National Institute of Standardization, Beijing, China

¹⁶. Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

¹⁷. State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China

¹⁸. Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China

¹⁹. National Institute of Metrology, Beijing, China

²⁰. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

²¹. Institute of Scientific and Technical Information of China, Beijing, China

²². Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, China

xiangp@mail.sysu.edu.cn

byhu@ioz.ac.cn

tbzhao@ioz.ac.cn

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Abstract

Human midbrain dopaminergic progenitors (mDAPs) are one of the most representative cell types in both basic research and clinical applications. However, there are still many challenges for the preparation and quality control of mDAPs, such as the lack of standards. Therefore, the establishment of critical quality attributes and technical specifications for mDAPs is largely needed. “Human midbrain dopaminergic progenitor” jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research, is the first guideline for human mDAPs in China. This standard specifies the technical requirements, test methods, inspection rules, instructions for usage, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for human mDAPs, which is applicable to the quality control for human mDAPs. It was originally released by the China Society for Cell Biology on 30 August 2022. We hope that the publication of this guideline will facilitate the institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of human mDAPs for clinical development and therapeutic applications.

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Yu-Kai Wang, Lin Feng, Ai-Jin Ma, Jie Hao, Ying Zhang, Yue-Jun Chen, Zhi-Guo Chen, Jun-Ying Yu, Yan Liu, Chang-Mei Liu, Yu Zhang, Chang-Lin Wang, Zhao-Qian Teng, Jia-Xi Zhou, Tian-Qing Li, Liu Wang, Bo-Qiang Fu, Yu Vincent Fu, Li-Jun Zhu, Ling-Min Liang, Jia-Ni Cao, Lei Wang, Qi Zhou, Andy Peng Xiang, Bao-Yang Hu, Tong-Biao Zhao. Human midbrain dopaminergic progenitors. Cell Proliferation, 2024, 57(4): e13563 https://doi.org/10.1111/cpr.13563